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Unleash the full power of human cells

Supercharge your skin and hair care treatments with the ultimate in exosomes

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For sale to cosmetics manufacturers and dermatologists only

hiEX™ Exosomes

Isolated from Applied StemCell’s clinical-grade human induced pluripotent stem cells (ActiCells™ GMP hiPSCs) using a proprietary process that ensures high yields of highly active exosomes, hiEX™ Exosomes are a significant advance in cosmetic exosome science.

REGENERATIVE

Because they are isolated from pluripotent stem cells, hiEX ™ Exosomes have more bioactive growth factors and nucleic acids than exosomes sourced from other cell types.

CONSISTENT

Unlike exosomes isolated from plants or mesenchymal stem cells (MSCs), hiEX™ Exosomes are isolated from a single iPSC line that is grown under highly consistent conditions in our GMP facility.

ETHICAL

hiEX™ Exosomes are cultured using animal-free media. The ActiCells™ hiPSC cell line is reprogrammed from cord blood cells obtained from a fully consented donor and has a drug master file (DMF)with the US FDA.

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Frequently asked questions

What are exosomes?

Exosomes are nanometer-sized vesicles that transport bioactive molecules

  • 50 – 300 nm vesicles
  • Normally shed by cells
  • Act as intercellular messengers and effectors
  • Filled with bioactive molecules from the parent cell
    • Growth factors
    • Proteins
    • RNA
    • Metabolites

Why use exosomes for skin and hair care?

Exosomes accelerate enhanced results across a range of applications

SKINCARE COSMETICS

Exosomes can promote collagen formation, tissue regeneration, inhibit UV photoaging, and have anti-inflammatory properties.1, 2

SCAR REVISION

Stem cell-derived exosomes are being used in keloid and hypertrophic care treatments, with the reduction of scars and stretch marks a rapidly emerging application.1

HAIR REGENERATION

Exosomes derived from stem cells can stimulate hair follicles and promote hair growth.1

SKIN REJUVENATION

Doctors are using exosomes to address skin problems such as acne, eczema, herpes cold sores, inflammation, rosacea, wound healing, and wrinkles.1

LASER AFTERCARE

MICRONEEDLING RECOVERY

UV-PROTECTIVE SUNSCREEN

TATTOO HEALING

ANTI-AGING SERUM

WRINKLE REDUCING CREAM

MICRONEEDLING HAIR REGENERATION

HAIR GROWTH SERUM

Why use hiEX™ Exosomes?

hiEX™ Exosomes are the ultimate in exosomes

  • Isolated from ActiCells™ hiPSCs* for enhanced regenerative potential
  • Available at 10x higher concentrations than MSC exosomes due to Applied StemCell’s proprietary manufacturing processes
  • Consistent from batch-to-batch because they are isolated from a single, genetically homogenous cell line, unlike MSCs which must be harvested from individual donors
  • Can be customized with growth factors using Applied StemCell’s genome editing expertise
*ActiCells™ hiPSCs are Applied StemCell’s GMP-grade iPSCs that have a DMF with the US FDA.

See how hiEX™ Exosomes can deliver the results your customers are looking for—start a converation with us today.

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Why use exosomes from iPSCs?

Exosomes from iPSCs outperform exosomes from other cell types

Unlike embryonic and adult mesenchymal stem cells, iPSCs do not have to be repeatedly harvested from donors. Instead, like all iPSCs, ActiCells™ hiPSCs are reprogrammed and established from a single, fully consented donor, ensuring consistency from batch to batch.

  • Up to 3x wider variety of bioactive molecules than exosomes isolated from MSCs3, 4

  • Increased therapeutic effects on healing and cellular repair compared to MSCs3-5

  • Consistent from batch to batch

About Applied StemCell

Founded in 2008 to provide industry and academic researchers with the ability to leverage the power of induced pluripotent stem cells (iPSC) and gene editing, Applied StemCell continues to use our innovative technologies to power the discovery and development of advanced therapeutics, and now cosmeceuticals.

Our products and services enable the full spectrum of basic research to GMP manufacturing—including disease modeling, iPSC services, mammalian cell line engineering, and nonclinical and pre-IND studies—and our patented technologies ensure a clear IP path to commercialization.

Contact Us

Complete the form below to start a conversation about using hiEX™ Exosomes in your skin and hair care formulations. We will get in touch with you within one business day.

References

  1. Thakur, et al. Therapeutic Values of Exosomes in Cosmetics, Skin Care, Tissue Regeneration, and Dermatological Diseases. Cosmetics. 2023; 10(2):65. https://doi.org/10.3390/cosmetics10020065.
  2. Oh, et al. Exosomes Derived from Human Induced Pluripotent Stem Cells Ameliorate the Aging of Skin Fibroblasts. International Journal of Molecular Sciences. 2018; 19(6):1715. https://doi.org/10.3390/ijms19061715.
  3. Wang, et al. Comparison of exosomes derived from induced pluripotent stem cells and mesenchymal stem cells as therapeutic nanoparticles for treatment of corneal epithelial defects. Aging (Albany NY). 2020;12(19):19546-19562. doi:10.18632/aging.103904.
  4. La Greca, et al. Extracellular vesicles from pluripotent stem cell-derived mesenchymal stem cells acquire a stromal modulatory proteomic pattern during differentiation. Exp Mol Med. 2018;50(9):1-12. Published 2018 Sep 10. doi:10.1038/s12276-018-0142-x.
  5. Liu, et al. Highly Purified Human Extracellular Vesicles Produced by Stem Cells Alleviate Aging Cellular Phenotypes of Senescent Human Cells. Stem Cells. 2019;37(6):779-790. doi:10.1002/stem.2996.

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