The ultimate in exosomes

hiEX™ Exosomes

Regenerative. Consistent. Ethical.

Advanced aesthetic care powered by stem cell technology

Exosomes in cosmetics—fad or for real?

The latest buzzy skin and hair care ingredient, exosomes are everywhere.

But do they work?

The data from the lab is promising, but not all exosomes are the same. We created hiEX™ Exosomes because the science shows that exosomes from induced pluripotent stem cells (iPSCs)—a technology that won the 2012 Nobel Prize in Medicine—have tremendous potential for fighting the visible signs of aging, promoting hair growth, and rejuvenating skin^1-3.

We believe that exosomes are the real thing and will have a significant impact on cosmetics and health in the years to come—and that the most potent and effective source of cosmetic exosomes for skin and hair are iPSCs.

Isolated from lab-grown stem cells (iPSCs), hiEX™ Exosomes are the ultimate in exosomes.

REGENERATIVE

Because they are isolated from lab-grown stem cells, hiEX ™ Exosomes have more bioactive growth factors and nucleic acids than exosomes sourced from other cell types.

CONSISTENT

Unlike exosomes isolated from plants or mesenchymal stem cells (MSCs), hiEX™ Exosomes are isolated from a single, lab-grown stem cell line that is cultured under highly consistent conditions in our GMP facility.

ETHICAL

hiEX™ Exosomes are isolated from cells grown under pharmaceutical-grade conditions and do not include any animal or fetus-derived material.

Frequently asked questions

What are exosomes?

Exosomes are tiny particles that your cells use to communicate with each other

You can think of them as the body’s natural messengers—carrying important information in the form of proteins, growth factors, and other signals from one cell to another.

Even though they’re much smaller and simpler than cells, exosomes can play a big role in how your skin and hair follicles repair themselves, stay hydrated, and maintain a youthful look.

In the lab, exosomes have been shown to:

Promote regeneration and fight inflammation^1-2
Improve skin problems like inflamamation, rosacea, and wrinkles¹
Stimulate hair follicles and promote hair growth¹
Reverse aging in skin, hair, cognitive behavior, and memory function³

What are hiEX™ Exosomes?

hiEX™ Exosomes are a special type of exosome isolated from lab-grown stem cells called iPSCs

Many exosomes used in today’s cosmetics come from plants or stem cells isolated from donated tissue.

hiEX™ Exosomes are different.

Unlike plant exosomes, hiEX™ Exosomes are isolated from a special kind of lab-grown stem cell called an iPSC, a technology that won the Nobel Prize in Medicine in 2012. They are filled with growth factors and other molecules that have been designed by millennia of evolution to work on the human body.

Unlike exosomes from mesenchymal stem cells (MSCs), which must be isolated from donated human tissue and can vary depending on the donor, hiEX™ Exosomes are consistent from batch to batch.

This consistency is because hiEX™ Exosomes come from a single iPSC line that is grown under tightly controlled, pharmaceutical-grade conditions.

How are hiEX™ Exosomes used in skin and hair care?

hiEX™ Exosomes are designed to boost your skin’s natural rejuvenation processes at home as well as during or after microneedling, peels, and laser treatments through topical application

At your treatment center

At our treatment center, hiEX™ Exosomes are used in two ways to enhance your results:

During treatment, your aesthetician may pair hiEX™ Exosomes with microneedling to deliver them deep into the skin and hair follicles for optimal absorption and rejuvenation.

Post-procedure, a sterile, highly concentrated hiEX™ Exosome solution is applied directly to the treated area to support natural healing and help minimize visible scarring.

At home

To further speed recovery, you can apply hiEX™ Exosome serum twice daily to the treated area starting 48 hours after treatment.

You can also use hiEX™ Exosome serum as part of your daily skincare regimen to reduce the visible signs of aging.

Where can I find hiEX™ Exosomes ?

hiEX™ Exosomes are only available through your aesthetic dermatologist.

Dermatologists and cosmetics manufacturers can learn more at cosmeceuticals.appliedstemcell.com/exosomes

hiEX™ Exosomes products are not intended to be drug products that diagnose, treat, cure, or prevent any disease or condition. These products have not been approved by the FDA and the statements have not been evaluated by the FDA.

About Applied StemCell

Applied StemCell is a biotechnology company based in California. Since 2008, we’ve been using advanced stem cell and gene editing technologies to help scientists discover new medicines and treatments.

Now, we’re bringing that same scientific expertise to skin and hair care. Our hiEX™ Exosomes are made using cutting-edge technology originally developed for medical research—and produced with the same care and quality used in pharmaceutical manufacturing.

Our mission is simple: to deliver safe, consistent, ethically produced, and effective exosomes that rejuvenate the appearance of your skin and hair.

References

Thakur, et al. Therapeutic Values of Exosomes in Cosmetics, Skin Care, Tissue Regeneration, and Dermatological Diseases. Cosmetics. 2023; 10(2):65. https://doi.org/10.3390/cosmetics10020065.
Oh, et al. Exosomes Derived from Human Induced Pluripotent Stem Cells Ameliorate the Aging of Skin Fibroblasts. International Journal of Molecular Sciences. 2018; 19(6):1715. https://doi.org/10.3390/ijms19061715.
Bi Y, Qiao X, Cai Z, et al. Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells. Cell Metabolism. 2025;37(2). doi:10.1016/j.cmet.2024.11.013

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